However, in vitro and in some patients, a negative inotropic effect has been observed. Nicardipine reduced afterload without impairing myocardial contractility in preliminary hemodynamic studies of CHF patients.The mechanism of this effect has not been established. Induction or exacerbation of angina has been seen in less than 1% of coronary artery disease patients treated with nicardipine. Increases in frequency, duration, or severity of angina have been seen in chronic oral therapy with nicardipine capsules.However, as with any antihypertensive agent, blood pressure lowering should be accomplished over as long a time as is compatible with the patient’s clinical status. No clinical events have been reported suggestive of a too rapid decrease in blood pressure with nicardipine.Avoid systemic hypotension when administering the drug to patients who have sustained an acute cerebral infarction or hemorrhage. Nicardipine may occasionally produce symptomatic hypotension or tachycardia. In administrating nicardipine, close monitoring of blood pressure and heart rate is required.Reduction of diastolic pressure in these patients may worsen rather than improve myocardial oxygen balance. Important Safety Information for Nicardipine Hydrochloride in 0.9% Sodium Chloride Injection:ĭo not use nicardipine in patients with advanced aortic stenosis because of the afterload reduction effect of nicardipine. Cardene® is a registered trademark of Baxter International Inc. Today one in every six injectable generic medicines used in US hospitals is a Hikma product. Hikma is the third largest US supplier of generic injectable medicines by volume, with a growing portfolio of over 100 products. “Hikma also markets Nicardipine in 10mL vials and we are pleased to expand our portfolio with this launch, broadening the choice of medicines available to hospitals.” “Nicardipine Hydrochloride Injection is an important medicine used to treat hypertension and Hikma is proud to introduce the first generic Nicardipine in ready to use bags,” said Riad Mishlawi, President of Injectables. For prolonged control of blood pressure, patients are transferred to oral medication as soon as their clinical condition permits.Īccording to IQVIA, US sales of Nicardipine Hydrochloride in 0.9% Sodium Chloride Injection, 200mL, were approximately $82 million in the 12 months ending January 2020. Nicardipine Hydrochloride Injection is indicated for the short-term treatment of hypertension when oral therapy is not feasible or desirable.
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